Hey there 
My two cent: there are pros and cons to every approach 
I’m very biased of course but, based on everything you mentioned @benFortunato, I think WeWeb could be a good fit for you.
Here’s what I’m thinking:
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you can definitely built a marketplace MVP without performance being an issue so at least, you can get your project off the ground and take it from there
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for scale, I think you should be fine because we have marketplaces with millions of items. One thing’s for sure though, you’ll need to learn about backend filters and pagination!
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again, super biased here but, as a nocoder myself, one of the things I love about WeWeb (and other tools like Webflow for example) is that the skills you learn building on our platform are transferrable to other tools with a similar approach (those that stay close to the underlying code). I love this because little by little, you get to understand code better and even write it if it’s something that you’re interested in learning
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as @Broberto mentioned, React vs WeWeb, I would say WeWeb would be a better fit for you because it’d be similar SEO performance with a more gentle learning curve.
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For Bubble vs WeWeb, I would also say WeWeb is a better fit because our integration with Xano is seamless (there’s also a bonus that you can have static pages with pre-rendered content but that’s suitable for smaller projects. if your marketplace grows to thousands of items, you’ll need to move to dynamic data)
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For Medusa + Nextjs vs WeWeb, I think both could work. With WeWeb, you would most likely build and iterate faster while Medusa + Nextjs would allow you to learn awesome skills and push search engine optimization further with server-side rendering.
Ok, hopefully that helps! Like @dorilama, I can only encourage you to continue doing your due diligence and figure out what’s the best fit for you! No matter what approach you choose, you will learn a lot and run into many obstacles but I’m sure it’ll be worth it! 